QS ENDO Real – A Study by the German Endometriosis Research Foundation (SEF) on the Reality of Care for Patients with Endometriosis in Germany, Austria and Switzerland.

Physicians’ knowledge of genetics and genetic tests.

by
Physicians' knowledge of genetics and genetic tests.
Questionnaires had been mailed in 1991 to 1,795 major care physicians (household physicians, internists, pediatricians, obstetrician-gynecologists) and psychiatrists who had graduated from medical college between 1950 and 1985 (67.6% of the pattern had graduated after 1970) and who had been members of skilled societies. The questions elicited demographic and observe traits in addition to knowledge of genetics ideas and details and consciousness of the provision of genetic exams. To validate the questionnaire, 360 medical geneticists and genetic counselors acquired questionnaires. Statistical evaluation concerned arc-sine operate transformation, t-tests, analyses of variance, F-tests, Tukey’s HSD, and stepwise a number of regression.
A complete of 1,140 (64.8%) of the non-geneticist physicians responded. They appropriately answered a median of 73.9%, SD, 13.9%, of the knowledge objects, in contrast with 94.6%, SD, 4.2%, for the genetics professionals (p < .001). The most important predictors of knowledge had been recency of commencement from medical college and practising in major care specialties by which publicity to genetics issues is probably going. Other important predictors (from most to least essential) had been commencement from a U.S. medical college, willingness to undertake a brand new predictive take a look at earlier than it turns into commonplace observe, not utilizing pharmaceutical firms as a supply of details about new medical practices, and taking a required genetics course in medical college.
The outcomes counsel that knowledge of genetics and genetic exams is growing amongst physicians, significantly amongst more moderen graduates and physicians who’re uncovered to genetics issues of their practices, however deficiencies stay. Although a medical college course in genetics could enhance knowledge, it’s not enough. Greater emphasis is required in any respect ranges of medical schooling to cut back the prospect of doctor error as extra genetic exams turn into out there. DNA testing for home cat ailments and look traits is a quickly rising asset for veterinary drugs.

Approximately 33 genes comprise 50 mutations that trigger feline well being issues or alterations within the cat’s look. A range of industrial laboratories can now carry out cat genetic diagnostics, permitting each the veterinary clinician and the personal proprietor to acquire DNA take a look at outcomes. DNA is definitely obtained from a cat through a buccal swab with an ordinary cotton bud or cytological brush, permitting DNA samples to be simply despatched to any laboratory on this planet. The DNA take a look at outcomes determine carriers of the traits, predict the incidence of traits from breeding applications, and affect medical prognoses and therapies. An total purpose of figuring out these genetic mutations is the correction of the defect through gene therapies and designer drug therapies.

Frontotemporal dementia: genetics and genetic counseling dilemmas.

Frontotemporal dementia (FTD) is a neurodegenerative illness with early signs of persona change and/or language dysfunction. Approximately 40% of people with FTD have a household historical past of dementia; nonetheless, in our expertise, lower than 10% have clear autosomal dominant inheritance. Mutations within the microtubule-associated protein tau (MAPT) gene have been reported in as much as 50% of hereditary instances, however are uncommon besides in households with greater than Three people with FTD. The genetics of FTD is difficult by medical heterogeneity, variable expression, phenocopies, misdiagnoses, and misplaced household histories.
The complexity of FTD genetics and genetic counseling are illustrated utilizing Four case histories. Case 1 demonstrates the problem acquiring a dependable FTD household historical past. Case 2 illustrates how psychiatric phenocopies could make household linkage research troublesome. The lack of genotype and phenotype correlation and points of predictive genetic testing inside FTD households are the topic of case 3, and case Four reveals how regular getting older language difficulties and cognitive adjustments will be misinterpreted when a household historical past of dementia is current.
Physicians seeing sufferers with potential FTD needs to be conscious of the chance of a genetic etiology. A 3-generation household historical past needs to be obtained with consideration to neurologic, psychiatric, and behavioral signs. Variable expression and phenocopies are confounding components when assessing a potential genetic etiology. Referral of the affected person and household for genetic counseling is really useful. The goal of this paper is to allow physicians to acknowledge hereditary patterns and genetic issues of FTD households and to grasp genetic counseling methods.
Physicians' knowledge of genetics and genetic tests.

Genetic range and genetic burden in people.

We talk about classes of genetic range in people. Neutral range, inhabitants variations in frequencies of genetic markers that we expect are invisible to pure choice, gives a passive file of inhabitants historical past however is in any other case of little curiosity in human biology. Genetic variation associated to illness will be separated into mutational noise and variation on account of choice, both ongoing choice else results of a previous atmosphere. We name genetic variation that causes impairment of well being or well-being of particular person people “obvious genetic burden” and variation that has results on health however not well-being “unapparent genetic burden”.

We use “burden” to tell apart these notions from the classical idea of “genetic load” that refers to results on inhabitants health, an idea formulated by Morton et al. We distinguish tailored genes and tailored genotypes: an tailored gene is a gene that will increase health of its bearer both in heterozygous or homozygous state or each, whereas an tailored genotype is a genotype that will increase health of its bearer however shouldn’t be transmitted intact to future generations.

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

Anti-Apoptosis inhibitor 5/API5 Antibody
PA1009 100ug/vial
EUR 334

Anti-Bax (Apoptosis Marker) Monoclonal Antibody
M00183 100ug/vial
EUR 397
Description: Mouse Monoclonal Bax (Apoptosis Marker) Antibody. Validated in IF, IHC and tested in Human, Monkey.

anti-Apoptosis enhancing nuclease
YF-PA20583 50 ug
EUR 363
Description: Mouse polyclonal to Apoptosis enhancing nuclease

anti-Cellular Apoptosis Susceptibility
YF-PA23522 50 ul
EUR 334
Description: Mouse polyclonal to Cellular Apoptosis Susceptibility

Histone H3 Phosphorylation Antibody Panel Pack
C10014 3 x 25 µg
EUR 628.55
Description: kits suitable for this type of research

Anti-Prostate Apoptosis Response Protein-4 Antibody
A03637 100ul
EUR 397
Description: Rabbit Polyclonal Prostate Apoptosis Response Protein-4 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Apoptosis repressor with CARD/NOL3 Antibody
PA1793 100ug/vial
EUR 294

anti-Cellular Apoptosis Susceptibility (2B7)
LF-MA10074 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (2C10)
YF-MA10197 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (2F4)
YF-MA10198 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (3F8)
YF-MA10199 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (3D8)
YF-MA10200 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Apoptosis inhibitor 5 (1C2)
YF-MA11077 100 ug
EUR 363
Description: Mouse monoclonal to Apoptosis inhibitor 5

Anti-Cellular Apoptosis Susceptibility (1E4)
YF-MA12554 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (1E4)
YF-MA12555 200 ul
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (2C10)
YF-MA12556 200 ul
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (2F4)
YF-MA12557 200 ul
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (3F8)
YF-MA12558 200 ul
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (1C1)
YF-MA12559 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (1C4)
YF-MA12560 100 ug
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Anti-Cellular Apoptosis Susceptibility (1C4)
YF-MA12561 200 ul
EUR 363
Description: Mouse monoclonal to Cellular Apoptosis Susceptibility

Chemical phosphorylation amidite, 250 mg
22560 250 mg
EUR 193

Chemical phosphorylation amidite, 5 g
62560 5 g
EUR 1426

Chemical phosphorylation amidite, 1 g
42560 1 g
EUR 349

EnzyFluo AMPK Phosphorylation Assay Kit
EAMPK-100 100
EUR 545
Description: For quantitative fluorescent immunoenzymatic assay of AMPK phosphorylation status in cultured cells. Method: FL360/450nm, 530/585nm. Samples: cells. Species: human, mouse, rat. Procedure: 3 hrs (hands-on time). Size: 100 tests.

EnzyFluo ERK Phosphorylation Assay Kit
EERK-100 100
EUR 556
Description: For quantitative fluorescent immunoenzymatic assay of ERK1/2 phosphorylation status in cultured cells. Method: FL360/450nm, 530/585nm. Samples: cells. Species: human, mouse, rat.. Procedure: 3 hrs (hands-on time). Size: 100 tests.

EnzyFluo NFkB Phosphorylation Assay Kit
ENFKB-100 100
EUR 545
Description: For quantitative fluorescent immunoenzymatic assay of NFκB phosphorylation status in cultured cells. Method: FL360/450nm, 530/585nm. Samples: cells. Species: human, mouse. Procedure: 3 hrs (hands-on time). Size: 100 tests.

Calcium-Binding Tyrosine Phosphorylation-Regulated Protein (CABYR) Antibody
20-abx111304
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Calcium-Binding Tyrosine Phosphorylation-Regulated Protein (CABYR) Antibody
20-abx148788
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Calcium-Binding Tyrosine Phosphorylation-Regulated Protein (CABYR) Antibody
abx340188-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Calcium-Binding Tyrosine Phosphorylation-Regulated Protein (CABYR) Antibody
abx231170-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Chemical Phosphorylation Reagent I (CPR I)
6001 1 g
EUR 480
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Human Glycogen phosphorylation(GP)ELISA Kit
QY-E05461 96T
EUR 361

Apoptosis-enhancing nuclease antibody
22725-100ul 100ul
EUR 390

Apoptosis enhancing nuclease antibody
70R-13466 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal Apoptosis enhancing nuclease antibody

Cellular Apoptosis Susceptibility Antibody
49774-100ul 100ul
EUR 333

Cellular Apoptosis Susceptibility Antibody
49774-50ul 50ul
EUR 239

Cellular Apoptosis Susceptibility Antibody
abx030969-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Cellular Apoptosis Susceptibility Antibody
abx030969-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx009320
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
abx025430-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
abx025430-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
20-abx005313
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (Dyrk1b) Antibody
abx028179-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (Dyrk1b) Antibody
abx028179-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
20-abx003172
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx176210
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx176211
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
20-abx112184
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (Dyrk4) Antibody
20-abx112185
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (DYR1A) Antibody
20-abx119074
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx128317
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
20-abx133669
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx135705
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
abx122510-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
20-abx147533
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx172170
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYR1B) Antibody
20-abx013869
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (Dyrk1a) Antibody
abx031012-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (Dyrk1a) Antibody
abx031012-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
abx033457-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
abx033457-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 3 (DYRK3) Antibody
abx033458-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 3 (DYRK3) Antibody
abx033458-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
abx033459-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
abx033459-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
abx033472-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
abx033472-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
abx033473-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
abx033473-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (Dyrk4) Antibody
abx028415-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (Dyrk4) Antibody
abx028415-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2) Antibody
20-abx320190
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
20-abx329453
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
abx331760-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
20-abx325860
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
20-abx323377
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
abx431220-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
20-abx301717
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 3 (DYRK3) Antibody
20-abx303688
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) Antibody
abx232592-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody
abx232593-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Apoptosis inhibitor
2783-25
EUR 457

Apoptosis inhibitor
2783-5
EUR 153

Apoptosis Inhibitor
A1930-10 10 mg
EUR 142
Description: M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay.

Apoptosis Inhibitor
A1930-100 100 mg
EUR 456
Description: M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay.

Apoptosis Inhibitor
A1930-25 25 mg
EUR 235
Description: M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay.

Apoptosis Inhibitor
A1930-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay.

Apoptosis Inhibitor
A1930-S Evaluation Sample
EUR 81
Description: M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay.

Rabbit Dual specificity tyrosine- phosphorylation- regulated kin
ELI-27714Ra 96 Tests
EUR 928

Apoptosis Inhibitor 5 (API5) Antibody
20-abx007291
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx008513
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BFAR) Antibody
20-abx006121
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Inducing Factor (AIF) Antibody
20-abx175443
  • EUR 1247.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Factor Related Apoptosis (FAS) Antibody
20-abx176352
  • EUR 1372.00
  • EUR 648.00
  • 1 mg
  • 200 ug
  • Please enquire.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx211347
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx211348
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102355
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102356
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102357
  • EUR 356.00
  • EUR 133.00
  • EUR 1024.00
  • EUR 509.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102358
  • EUR 356.00
  • EUR 133.00
  • EUR 1024.00
  • EUR 509.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102359
  • EUR 398.00
  • EUR 133.00
  • EUR 1066.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx102360
  • EUR 398.00
  • EUR 133.00
  • EUR 1066.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Apoptosis Inducing Factor (AIF) Antibody
20-abx102410
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx104789
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx128094
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (Fas) Antibody
abx038135-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx128470
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx129940
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx130140
  • EUR 398.00
  • EUR 133.00
  • EUR 1066.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx130850
  • EUR 411.00
  • EUR 133.00
  • EUR 1163.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

BCL2, Apoptosis Regulator (BCL2) Antibody
20-abx159344
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BAR) Antibody
20-abx142064
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx172320
  • EUR 718.00
  • EUR 384.00
  • 1 mg
  • 200 ug
  • Please enquire.

Factor Related Apoptosis (FAS) Antibody
20-abx172321
  • EUR 314.00
  • EUR 773.00
  • EUR 411.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Apoptosis Inducing Factor (AIF) Antibody
20-abx171293
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
  • Please enquire.

Apoptosis Inducing Factor (AIF) Antibody
20-abx171294
  • EUR 871.00
  • EUR 453.00
  • 1 mg
  • 200 ug
  • Please enquire.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx171295
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.

Apoptosis Inducing Factor (AIF) Antibody
abx011979-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BFAR) Antibody
abx029013-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BFAR) Antibody
abx029013-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
abx030586-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
abx030586-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx270037
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-12 working days.

Factor Related Apoptosis (FAS) Antibody
20-abx270229
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Cellular Apoptosis Susceptibility Conjugated Antibody
C49774 100ul
EUR 397

Bifunctional Apoptosis Regulator (BFAR) Antibody
20-abx339261
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BFAR) Antibody
20-abx339262
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx339647
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx339991
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Bifunctional Apoptosis Regulator (BFAR) Antibody
20-abx320837
  • EUR 439.00
  • EUR 328.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Apoptosis-Enhancing Nuclease (AEN) Antibody
20-abx308819
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx325828
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Apoptosis Inhibitor 5 (API5) Antibody
20-abx333766
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Factor Related Apoptosis (FAS) Antibody
abx430025-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Apoptosis Inducing Factor (AIF) Antibody
abx230235-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Apoptosis Inhibitor 5 (API5) Antibody
abx230482-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody (HRP)
20-abx311628
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody (FITC)
20-abx311629
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 4 (DYRK4) Antibody (Biotin)
20-abx311630
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Cabyr ELISA Kit| Mouse Calcium-binding tyrosine phosphorylation
EF014364 96 Tests
EUR 689

Apoptosis activator 2
2784-25
EUR 414

Apoptosis activator 2
2784-5
EUR 142

Apoptosis Inducer Set
55R-1310 5 units
EUR 633
Description: Apoptosis Inducer Set for use in the research laboratory

Apoptosis Detection Kit
ANXVKB-100T 100 test
EUR 464.7

Apoptosis Detection Kit
ANXVKCFB-100T 100 test
EUR 412.7

Apoptosis Detection Kit
ANXVKCFB7-100T 100 test
EUR 412.7

Apoptosis Detection Kit
ANXVKDY-100T 100 test
EUR 389.3

Apoptosis Detection Kit
ANXVKF-100T 100 test
EUR 329.5

Apoptosis Detection Kit
ANXVKF7-100T 100 test
EUR 329.5

Apoptosis Detection Kit
ANXVKPE-100T 100 test
EUR 346.4

Apoptosis Activator 2
A4016-10 10 mg
EUR 123
Description: Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4?M [1].Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner.

Apoptosis Activator 2
A4016-25 25 mg
EUR 225
Description: Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4?M [1].Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner.

Apoptosis Activator 2
A4016-50 50 mg
EUR 361
Description: Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4?M [1].Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner.

Apoptosis-Inducing Factor
PR27201 5 ug
EUR 191

Piperlongumine (Apoptosis Inducer)
SIH-156-100MG 100 mg
EUR 409
  • Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1).
  • Show more
Description: The substance Piperlongumine is a apoptosis inducer. It is synthetically produced and has a purity of >98%. The pure substance is cream solid which is soluble in 25 mg/ml DMSO .

Piperlongumine (Apoptosis Inducer)
SIH-156-20MG 20 mg
EUR 166
  • Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1).
  • Show more
Description: The substance Piperlongumine is a apoptosis inducer. It is synthetically produced and has a purity of >98%. The pure substance is cream solid which is soluble in 25 mg/ml DMSO.

Deprenyl (Apoptosis Inhibitor)
SIH-209-100MG 100 mg
EUR 121
  • Deprenyl or Selegiline is a drug used for the treatment of early stage Parkinson's (1), depression and senile dementia (2). It is a selective irreversable inhibitor of monoamine oxidase B (MAO-b).
Description: The substance Deprenyl is a apoptosis inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is white solid which is soluble to 100 mM in water, and to 100 mM in ethanol.

Deprenyl (Apoptosis Inhibitor)
SIH-209-1G 1 g
EUR 222
  • Deprenyl or Selegiline is a drug used for the treatment of early stage Parkinson's (1), depression and senile dementia (2). It is a selective irreversable inhibitor of monoamine oxidase B (MAO-b).
Description: The substance Deprenyl is a apoptosis inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is white solid which is soluble to 100 mM in water, and to 100 mM in ethanol.

Andrographolide (Apoptosis Inducer)
SIH-220-100MG 100 mg
EUR 103
  • Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation
  • Show more
Description: The substance Andrographolide is a apoptosis inducer. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is DMSO.

Andrographolide (Apoptosis Inducer)
SIH-220-500MG 500 mg
EUR 220
  • Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation
  • Show more
Description: The substance Andrographolide is a apoptosis inducer. It is synthetically produced and has a purity of >98%. The pure substance is off-white solid which is DMSO.

Balanced polymorphisms by which the heterozygote is superior in health could generate most tailored genotypes. In the face of main speedy environmental change tailored genotypes seem first however over time they’re changed by tailored genes. The presence of tailored genotypes is an effective indication of current environmental change: for instance, there are apparently many polymorphisms in home animals of this nature, responses to domestication, and many fewer in wild animals (and in people). We distinguish penalties of genetic range for health, related to evolution, and penalties for well-being, related to drugs and public well being.

Chemical genetics and orphan genetic diseases.

by
Chemical genetics and orphan genetic diseases.

Many orphan ailments have been recognized that individually have an effect on small numbers of sufferers however cumulatively have an effect on roughly 6%-10% of the European and United States populations. Human genetics has turn out to be more and more efficient at figuring out genetic defects underlying such orphan genetic ailments, however little progress has been made towards understanding the causal molecular pathologies and creating focused therapies. Chemical genetics, positioned on the interface of chemistry and genetics, can be utilized for elucidation of molecular mechanisms underlying ailments and for drug discovery.

This overview discusses latest advances in chemical genetics and how small-molecule instruments can be utilized to review and finally deal with orphan genetic ailments. We focus right here on a case examine involving spinal muscular atrophy, a pediatric neurodegenerative illness brought on by homozygous deletion of the SMN1 (survival of motor neuron 1) gene. The previous few a long time have seen the sector of genetic engineering evolve at a fast tempo, with neuroscientists now geared up with a variety of instruments for the manipulation of an animal’s genome with the intention to examine mind operate.

However, the variety of species to which these applied sciences have been utilized, specifically the fruit fly, C. elegans, zebrafish and mouse, stays comparatively few. This overview will focus on the number of approaches to genetic modification which were developed in such conventional ‘genetic techniques’, and spotlight the progress that has been made to translate these applied sciences to different species resembling rats, monkeys and birds, the place sure neurobiological questions could also be higher studied.

Judaism, genetic screening and genetic remedy.

Genetic screening, gene remedy and different functions of genetic engineering are permissible in Judaism when used for the remedy, treatment, or prevention of illness. Such genetic manipulation shouldn’t be thought of to be a violation of God’s pure legislation, however a reliable implementation of the biblical mandate to heal. If Tay-Sachs illness, diabetes, hemophilia, cystic fibrosis, Huntington’s illness or different genetic ailments will be cured or prevented by “gene surgical procedure,” then it’s actually permitted in Jewish legislation. Genetic premarital screening is inspired in Judaism for the aim of discouraging at-risk marriages for a deadly sickness resembling Tay-Sachs illness.

Neonatal screening for treatable situations resembling phenylketonuria is actually fascinating and maybe required in Jewish legislation. Preimplantation screening and the implantation of solely “wholesome” zygotes into the mom’s womb to forestall the delivery of an affected youngster are in all probability sanctioned in Jewish legislation. Whether or not these assisted copy strategies could also be used to decide on the intercourse of 1’s offspring, to forestall the delivery of a kid with a sex-linked illness resembling hemophilia, has not but been dominated on by fashionable rabbinic choices.

Prenatal screening with the particular intent of aborting an affected fetus shouldn’t be allowed in keeping with most rabbinic authorities, though a minority view permits it “for excellent want.” Not to have kids if each dad and mom are carriers of genetic ailments resembling Tay-Sachs shouldn’t be a Jewish possibility. Preimplantation screening is preferable. All screening take a look at outcomes should stay confidential. Judaism doesn’t allow the alteration or manipulation of bodily traits and traits resembling peak, eye and hair colour, facial options and the like, when such change offers no helpful profit to mankind. On the opposite hand, it’s permissible to clone organisms and microorganisms to facilitate the manufacturing of insulin, progress hormone, and different brokers meant to learn mankind and to treatment and deal with ailments.

Chemical genetics and orphan genetic diseases.

Genetics and genetic testing for glaucoma.

In latest a long time, investigators have recognized quite a few genes and genetic elements that trigger or contribute danger for glaucoma. These findings have elevated our understanding of illness mechanisms, supplied us with new diagnostic instruments, and might permit for growth of improved therapies for glaucoma. However, genetic testing is most helpful when it’s reserved for acceptable sufferers. The goal of this text is to overview key factors and latest developments relating to the genetics and genetic testing for glaucoma and to supply suggestions for when genetic testing could also be warranted.
Large genome-wide affiliation research have recognized a number of new susceptibility loci related to main open angle glaucoma and main angle closure glaucoma. Several glaucoma-causing genes and genetic danger elements for glaucoma have been found. As a consequence, there are particular medical eventualities by which genetic testing is warranted. In choose instances (i.e., familial juvenile open angle glaucoma), genetic testing can function a robust instrument to enhance diagnostic accuracy, effectivity of illness surveillance, and collection of remedy, enabling physicians to raised optimize care for his or her sufferers.

Annexin V-Cy3 Apoptosis Kit
K102-25
EUR 207

Annexin V-Cy3 Apoptosis Kit
K102-400
EUR 958

Annexin V Apoptosis Detection Kit (CY3)
55R-1266 25 assays
EUR 277
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory

Annexin V-Cy3 Apoptosis Kit Plus
K202-100
EUR 490

Annexin V-Cy3 Apoptosis Kit Plus
K202-25
EUR 240

Annexin V-Cy3 Apoptosis Kit Plus
K202-400
EUR 947

Annexin V-Cy3 Apoptosis Kit Plus
K2058-100 100 assays
EUR 516

Annexin V-Cy3 Apoptosis Kit Plus
K2058-25 25 assays
EUR 251

Annexin V-Cy3 Apoptosis Kit Plus
K2058-400 400 assays
EUR 1059

Annexin V Apoptosis Detection Kit Plus (CY3)
55R-1303 25 assays
EUR 296
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory

Annexin V-FITC Apoptosis Kit
K2003-100 100 assays
EUR 516

Annexin V-FITC Apoptosis Kit
K2003-25 25 assays
EUR 238

Annexin V-FITC Apoptosis Kit
K2003-400 400 assays
EUR 1114

Annexin V-Cy5 Apoptosis Kit
K2005-100 100 assays
EUR 516

Annexin V-Cy5 Apoptosis Kit
K2005-25 25 assays
EUR 238

Annexin V-Cy5 Apoptosis Kit
K2005-400 400 assays
EUR 1114

Annexin V-EGFP Apoptosis Kit
K2006-100 100 assays
EUR 516

Annexin V-EGFP Apoptosis Kit
K2006-25 25 assays
EUR 238

Annexin V-EGFP Apoptosis Kit
K2006-400 400 assays
EUR 1114

Annexin V-Biotin Apoptosis Kit
K2009-100 100 assays
EUR 516

Annexin V-Biotin Apoptosis Kit
K2009-25 25 assays
EUR 238

Annexin V-Biotin Apoptosis Kit
K2009-400 400 assays
EUR 1114

Annexin V-FITC Apoptosis Kit
K101-100
EUR 512

Annexin V-FITC Apoptosis Kit
K101-25
EUR 224

Annexin V-FITC Apoptosis Kit
K101-400
EUR 1023

Annexin V-Cy5 Apoptosis Kit
K103-100
EUR 512

Annexin V-Cy5 Apoptosis Kit
K103-25
EUR 218

Annexin V-Cy5 Apoptosis Kit
K103-400
EUR 1023

Annexin V-EGFP Apoptosis Kit
K104-100
EUR 501

Annexin V-EGFP Apoptosis Kit
K104-25